Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder among females of reproductive age. Many emerging contaminants in personal care products have been confirmed with endocrine disruptive effects. We performed a case-control study to explore the association between the concentrations of certain emerging contaminants (organic UV filters, bisphenol A, and triclosan) and the risk of PCOS. Urine samples were collected from 40 women with PCOS (case group) and 83 healthy women (control group). No significant differences were found in detection rate or total concentrations of analytes in women with PCOS and controls (p > 0.05). In addition, no association was found between certain emerging contaminants and PCOS either in an unadjusted binary logistic regression model or in a model adjusted for potential confounders. However, with stratification according to body mass index, one organic UV filter - octocrylene(OC) was significantly associated with PCOS in women with BMI ≥ 24 (adjusted OR = 1.512, 95% CI: 1.043, 2.191). It's the first time to investigate the association between exposure of organic UV filters and PCOS risk. We conclude that there is positive association between OC and PCOS risk in obese and overweight women.

多囊卵巢综合征（PCOS）是育龄女性中最常见的内分泌疾病之一。已证实个人护理产品中的许多新兴污染物具有内分泌干扰作用。我们进行了一项病例对照研究，以探讨某些新兴污染物（有机紫外线过滤剂，双酚A和三氯生）的浓度与PCOS风险之间的关系。收集了40名PCOS妇女（病例组）和83名健康妇女（对照组）的尿液样本。患有PCOS和对照的女性的检测率或总分析物的浓度没有明显差异（p > 0.05）。此外，在未经调整的二元逻辑回归模型或针对潜在混杂因素调整的模型中，未发现某些新兴污染物与PCOS之间存在关联。但是，根据体重指数进行分层，在BMI≥24的女性中，一种有机紫外线过滤剂-辛二烯（OC）与PCOS显着相关（校正后的OR = 1.512，95％CI：1.043，2.191）。这是第一次研究有机紫外线过滤剂的暴露与PCOS风险之间的关系。我们得出结论，肥胖和超重妇女的OC和PCOS风险之间存在正相关。