Despite stated in some highly cited articles, magnetite is devoided of peroxidase activity. In fact, this very stable mixed valence Fe^IIO⋅Fe^III₂O₃ complex is not catalytically competent to oxidize standard peroxidase substrates, especially at the biologically relevant pH value of 7.4. In addition, magnetite whose deleterious redox activity has been suspected in Alzheimer's disease brain damages, does not significantly interact with amyloid peptide Aβ in vitro, and is not able to induce, either in the presence or absence of Aβ, the reductive activation of dioxygen, the first step of an oxidative stress. In fact, this highly insoluble mineral iron derivative is probably not involved in the oxidative damage of brain neurons of patients with AD.

中文翻译：

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磁铁矿Fe3O4没有固有的过氧化物酶活性，并且可能不参与阿尔茨海默氏症的氧化应激

尽管在一些引用率很高的文章中进行了说明，但磁铁矿缺乏过氧化物酶活性。实际上，这非常稳定的混合价的Fe ^II O⋅Fe ^III ₂ ö ₃复合物是未催化能力，以氧化标准过氧化物酶底物，特别是在7.4的生物学相关的pH值。此外，怀疑其有害的氧化还原活性在阿尔茨海默氏病脑损伤中起作用的磁铁矿，在体外与淀粉样肽Aβ没有明显的相互作用，并且在存在或不存在Aβ的情况下，都无法诱导双氧的还原性活化，氧化应激的第一步。实际上，这种高度不溶的矿物铁衍生物可能不参与AD患者脑神经元的氧化损伤。