Abstract Polypropylene is a synthetic plastic widely used in industry due to its low price and convenience. Although its wide applications, serious safety issues have been raised about toxic chemicals such as butylated hydroxytoluene (BHT) and pentaerythritol tetrakismethylene-(3,5-di-tert-butyl-4-hydroxyhydrocinnamate) (Irganox 1010) which may migrate from polypropylene packaging into foods. Here, the effects of severe processing conditions [autoclave heating (121 °C), microwave radiation (700 W), and freezer storage (−30 °C)] on migration behavior were confirmed. Mathematical models were used to estimate the migration behavior of these compounds, and the results were compared with data from real experimental analyses which were performed by high-performance liquid chromatography. Overall, the estimated values from the mathematical model were 1.5–2 times larger than the experimental values for all conditions, suggesting that the mathematical migration models provide reliable predictions of migration. Taken together, computational assessment of migration behavior may be an effective way to decrease the time and expense of food safety evaluations.

中文翻译：

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聚丙烯的实验和理论研究：抗氧化剂在不同食品模拟物和温度下的迁移

摘要 聚丙烯由于价格低廉、使用方便，是一种广泛应用于工业的合成塑料。尽管其应用广泛，但关于可能从聚丙烯包装中迁移的有毒化学品，如丁基化羟基甲苯 (BHT) 和季戊四醇四亚甲基-(3,5-二叔丁基-4-羟基氢化肉桂酸酯) (Irganox 1010)，已引起严重的安全问题进入食物。在这里，证实了严酷的加工条件 [高压釜加热 (121 °C)、微波辐射 (700 W) 和冷冻储存 (-30 °C)] 对迁移行为的影响。数学模型用于估计这些化合物的迁移行为，并将结果与​​由高效液相色谱进行的实际实验分析的数据进行比较。总体而言，数学模型的估计值为 1。比所有条件下的实验值大 5-2 倍，表明数学迁移模型提供了可靠的迁移预测。总之，迁移行为的计算评估可能是减少食品安全评估时间和费用的有效方法。