The activity of edible Nepeta nuda L. (Lamiaceae) tincture and Listerine towards a selected group of oral pathogenic microorganisms (4 bacterial and 9 fungal strains) has been explored. Their potentials to inhibit the formation of biofilm and to diminish established biofilm have been compared. The amount of N. nuda tincture and swishing time necessary for reaching better or equivalent antimicrobial effect than that of Listerine have been predicted. Phenolic compounds in N. nuda tincture are determined by LC-DAD/ESI-MSn. Both Listerine and N. nuda tincture possess good antimicrobial potentials (MIC in the range of 0.8–15 μL per well) including inhibition of biofilms. Rosmarinic acid and verminoside are the most dominant phenolic compounds present in the N. nuda tincture. Based on in vitro results, we infer that it is more desirable to swish 20 mL of mouthwashes (Listerine and N. nuda tincture, 100 mg mL⁻¹) for 30 s when dealing with selected microorganisms in general and for 60 s (N. nuda tincture) when dealing with bacterial biofilms.

中文翻译：

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食用荆芥的tin剂中酚类化合物的表征：抗菌漱口水的开发

已经研究了食用荆芥（Laceaceae）and和利斯特林对一组选定的口腔致病微生物（4种细菌和9种真菌菌株）的活性。比较了它们抑制生物膜形成和减少已建立的生物膜的潜力。可以预测到达到比Listerine更好或更等效的抗菌作用所必需的N. nuda cture剂和漱口时间。通过LC-DAD / ESI-MSn测定N ..中的酚类化合物。李斯特林和努达猪笼草具有良好的抗菌潜能（每孔MIC在0.8-15μL范围内），包括抑制生物膜。迷迭香酸和Verminoside是存在于N. nuda cture中的最主要的酚类化合物。根据体外结果，我们推断更一般的情况是，在处理选定的微生物时，一般要洗20毫升漱口水（李斯特菌和N.nuda cture剂，100 mg毫升^-1）30 s，再洗60 s（N.努达tin）处理细菌生物膜时。