Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy,Journal of Agricultural and Food Chemistry

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Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-09-19 00:00:00 , DOI: 10.1021/acs.jafc.8b04104
Angela R. Guerra _{1,

2} , Maria F. Duarte _{1,

3} , Iola F. Duarte ₂

Affiliation

Recognition of neoplastic metabolic reprogramming as one of cancer’s hallmarks has paved the way for developing novel metabolism-targeted therapeutic approaches. The use of plant-derived natural bioactive compounds for this endeavor is especially promising, due to their diverse structures and multiple targets. Hence, over the past decade, a growing number of studies have assessed the impact of phytochemicals on tumor cell metabolism, aiming at improving current knowledge on their mechanisms of action and, at the same time, evaluating their potential as anti-cancer metabolic modulators. In this Review, we focus on three classes of plant-derived compounds with promising anti-cancer activity—phenolic compounds, isoprenoids, and alkaloids—to describe their effects on major energetic and biosynthetic pathways of human tumor cells. Such a comprehensive and integrated account of the ability of these compounds to hit different metabolic targets is expected to contribute to the rational design and critical assessment of novel anti-cancer therapies based on natural-product-mediated metabolic reprogramming.

中文翻译：

用植物衍生的天然产物靶向肿瘤代谢：癌症治疗中的新兴趋势

将肿瘤代谢重编程作为癌症的标志之一，已为开发新的以代谢为目标的治疗方法铺平了道路。由于其结构多样和靶标多，将植物来源的天然生物活性化合物用于这一努力特别有希望。因此，在过去的十年中，越来越多的研究评估了植物化学物质对肿瘤细胞代谢的影响，旨在提高有关其作用机理的现有知识，同时评估其作为抗癌代谢调节剂的潜力。在本综述中，我们重点介绍三类具有前途抗癌活性的植物来源化合物（酚类化合物，类异戊二烯和生物碱），以描述它们对人类肿瘤细胞主要能量和生物合成途径的影响。

更新日期：2018-09-19

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