Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?,Journal of Agricultural and Food Chemistry

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Could Fecal Phenylacetic and Phenylpropionic Acids Be Used as Indicators of Health Status?
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-09-18 00:00:00 , DOI: 10.1021/acs.jafc.8b04102
Isabel Gutiérrez-Díaz _{1,

2} , Tania Fernández-Navarro _{1,

2} , Nuria Salazar _{2,

3} , Begoña Bartolomé ₄ , M. Victoria Moreno-Arribas ₄ , Patricia López _{1,

5} , Ana Suárez _{1,

5} , Clara G. de los Reyes-Gavilán _{2,

3} , Miguel Gueimonde _{2,

3} , Sonia González _{1,

2}

Affiliation

Although most of the health effects attributed to polyphenols may be linked to their phenolic-derived metabolites, the role of the intestinal derived-phenolics in human health is still far from being well understood. We determined the profile of fecal phenolic-derived metabolites, microbiota, biomarkers of oxidative stress and inflammation, and daily intake of bioactive compounds in 71 elderly volunteers. Phenylacetic and phenylpropionic acids were the main phenolic metabolites present in feces. From them, phenylacetic acid was related with a more pro-oxidant and immune stimulated status, and both were negatively associated with fecal propionate, whereas phenylpropionic acid was directly related with the fecal concentration of acetate. Moreover, phenylacetic acid was negatively associated with the Bacteroides group and Clostridium cluster XIVa and positively with Lactobacillus. These results provide a rationale to explore the potential of fecal microbial phenolic-derived metabolites as possible biomarkers of health status in future studies focused on the elderly population.

中文翻译：

粪便中的苯乙酸和苯丙酸能否用作健康状况的指标？

尽管归因于多酚的大多数健康影响可能与它们的酚类代谢产物有关，但肠源性酚类物质在人类健康中的作用仍远未得到很好的理解。我们确定了71名老年志愿者的粪便酚类代谢物，微生物群，氧化应激和炎症的生物标志物以及生物活性化合物的每日摄入量。苯乙酸和苯丙酸是粪便中主要的酚类代谢产物。苯乙酸与它们的促氧化剂状态和免疫刺激状态有关，二者与粪便丙酸酯呈负相关，而苯丙酸与粪便中乙酸的浓度直接相关。此外，苯乙酸与拟杆菌属呈负相关。组和梭状芽孢杆菌簇XIVa和乳酸菌阳性。这些结果为在未来针对老年人群的研究中探索粪便微生物酚类代谢产物作为健康状况的可能生物标志物的可能性提供了理论依据。

更新日期：2018-09-18

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