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Green, Solid-State Synthesis of Maleated Chitosan and Ionotropic Gelation with Chitosan
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2018-09-18 00:00:00 , DOI: 10.1021/acssuschemeng.8b03648
Kartik Ravishankar 1 , K. M. Shelly 1 , Raj Preeth Desingh 2 , Rajalakshmi Subramaniyam 2 , Abathodharanan Narayanan 1 , Raghavachari Dhamodharan 1
Affiliation  

We, for the first time, report a green, solid-state method for synthesizing maleated chitosan, wherein maleation is brought about by stirring chitosan flakes in molten maleic anhydride. In a similar manner, other derivatives like succinated chitosan could also be prepared. Maleated chitosan, given its polyanionic nature in solution form, could be further used to cross-link chitosan polycation through electrostatic complexation. The resulting “all-chitosan” gel, having very low cytotoxicity and a conducive surface for cell attachment, could be used as scaffolds for tissue engineering. In this context it is to be noted that presently, maleation of chitosan has been invariably carried out in solution phase, using harsh, environmentally aggressive solvents such as DMSO, DMF, acetamide and the like.

中文翻译:

马来酸化壳聚糖的绿色固态合成和壳聚糖的离子胶凝

我们首次报道了一种绿色,固态的马来酸化壳聚糖的合成方法,其中通过在熔融的马来酸酐中搅拌壳聚糖薄片来实现马来化。以类似的方式,也可以制备其他衍生物,例如琥珀酸化的壳聚糖。鉴于其呈溶液形式的聚阴离子性质,马来酸化的壳聚糖可进一步用于通过静电络合使壳聚糖聚阳离子交联。所得的“全壳聚糖”凝胶具有极低的细胞毒性和有利于细胞附着的表面,可用作组织工程的支架。在这种情况下,应当指出,目前,壳聚糖的马来酸化总是在溶液相中使用苛刻的,对环境有害的溶剂如DMSO,DMF,乙酰胺等进行的。
更新日期:2018-09-18
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