Hybrid Conducting Composite Films Based on Polypyrrole and Poly(2‐(diethylamino)ethyl methacrylate) Hydrogel Nanoparticles for Electrochemically Controlled Drug Delivery,Advanced Materials Interfaces

当前位置： X-MOL 学术 › Adv. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hybrid Conducting Composite Films Based on Polypyrrole and Poly(2‐(diethylamino)ethyl methacrylate) Hydrogel Nanoparticles for Electrochemically Controlled Drug Delivery
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2018-09-19 , DOI: 10.1002/admi.201800968
Eduart Gutiérrez-Pineda _{1,

2,

3} , Paolin Rocio Cáceres-Vélez _{2,

4} , María José Rodríguez-Presa ₁ , Sergio E. Moya ₂ , Claudio A. Gervasi _{1,

5} , Javier I. Amalvy _{1,

6}

Affiliation

A 3D conductive hybrid film is fabricated based on poly 2‐(diethylamino) ethyl methacrylate (PDEA) nanoparticles with polypyrrole (PPy) as the conductive component. PDEA nanoparticles are deposited on a gold substrate by drop casting. Then, PPy is electrochemically grown through the hydrogel nanoparticles as a semi‐interpenetrating polymer network. PDEA hydrogel nanoparticles reversibly swell at low pH while PPy liberates H⁺ in the oxidized state. The oxidation of PPy is used to create an electrostimulated decrease in pH in the PDEA/PPy hybrid film that results in film swelling. The electrochemical properties of the hybrid conductive composite film are studied through cyclic voltammetry and electrochemical impedance spectroscopy. Doxorubicin (Dox) as model drug is encapsulated in the PDEA/PPy hybrid composite film by a pH switch. Drug electroliberation is investigated at different applied potentials from −0.65 to +0.65 V. The amount of Dox released shows a dependence on the applied potential and the duration of the electrical stimuli. The (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) tetrazolium reduction assay is conducted to evaluate the impact of the electrocontrolled release of Dox on the proliferation of the A549 cell line, showing a decrease in cell viability, proportional to the applied potential and its duration.

中文翻译：

基于聚吡咯和聚（2-（二乙基氨基）乙基甲基丙烯酸乙酯）水凝胶纳米粒子的混合导电复合膜，用于电化学控制药物输送

以聚吡咯（PPy）为导电成分的聚2-（二乙氨基）甲基丙烯酸乙酯（PDEA）纳米粒子制成3D导电杂化膜。通过滴铸将PDEA纳米颗粒沉积在金基底上。然后，PPy通过水凝胶纳米颗粒作为半互穿聚合物网络进行电化学生长。PDEA水凝胶纳米颗粒在低pH值下可逆溶胀，而PPy释放H ⁺处于氧化状态。PPy的氧化用于在PDEA / PPy杂化膜中产生电刺激的pH降低，从而导致膜膨胀。通过循环伏安法和电化学阻抗谱研究了杂化导电复合膜的电化学性能。通过pH开关将作为模型药物的阿霉素（Dox）封装在PDEA / PPy杂化复合膜中。研究了在-0.65至+0.65 V的不同施加电势下的药物电解。释放的Dox量显示出对施加电势和电刺激持续时间的依赖性。进行了（3-（4,5-二甲基噻唑-2-基）-2-溴5-二苯基四唑鎓）四唑鎓还原试验，以评估Dox电控释放对A549细胞系增殖的影响，

更新日期：2018-09-19

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11