As mango leaf tea contains mangiferin and other bioactive compounds, this study investigated its anti-inflammatory, antioxidant and hepatoprotective effects on rats with high-fat induced obesity. Three groups were established: a control group (AIN93M diet), an obese group (high-fat diet HFD) and a treatment group (HFD with mango leaf tea for 8 weeks). Mango leaf tea increased antioxidant enzymes, total antioxidant capacity, AdipoR2 and PPAR-α mRNA and proteins expressions and, it also inhibited the NF-κB p65 and SREBP1c genes expressions in the liver. This beverage also leads to Cpt1 overexpression and a significant decrease in the accumulation of fat droplets, improving the hepatic steatosis. Molecular docking suggested a positive interaction between mangiferin, the main bioactive compound of mango leaf tea, and PPAR-α. Mango leaf tea exhibited a hepatoprotective effect through activating PPARα and decreasing the NF-κB p65 expressions, reducing oxidative stress and steatosis, and improving the lipid metabolism.

由于芒果叶茶含有芒果苷和其他生物活性化合物，因此本研究调查了其对高脂诱导肥胖大鼠的抗炎，抗氧化和保肝作用。建立了三组：对照组（AIN93M饮食），肥胖组（高脂饮食HFD）和治疗组（HFD加芒果叶茶治疗8周）。芒果叶茶增加了抗氧化酶，总抗氧化能力，AdipoR2和PPAR-αmRNA和蛋白质的表达，还抑制了肝脏中NF-κBp65和SREBP1c基因的表达。这种饮料还导致Cpt1过表达，并且脂肪滴的积聚显着减少，从而改善了肝脂肪变性。分子对接表明芒果叶茶的主要生物活性化合物芒果苷和PPAR-α之间存在正相互作用。