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Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery†
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-09-19 00:00:00 , DOI: 10.1039/c8lc00776d Hau Ran Cheong 1, 2, 3, 4 , Nam-Trung Nguyen 5, 6, 7 , Mei Kum Khaw 1, 2, 3, 4 , Boon Yew Teoh 1, 2, 3, 4 , Pei Song Chee 1, 2, 3, 4
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-09-19 00:00:00 , DOI: 10.1039/c8lc00776d Hau Ran Cheong 1, 2, 3, 4 , Nam-Trung Nguyen 5, 6, 7 , Mei Kum Khaw 1, 2, 3, 4 , Boon Yew Teoh 1, 2, 3, 4 , Pei Song Chee 1, 2, 3, 4
Affiliation
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This paper reports a wirelessly powered ionic polymer-metal composite (IPMC) soft actuator operated by external radio frequency (RF) magnetic fields for targeted drug delivery. A 183 μm thick IPMC cantilever valve was fitted with an embedded LC resonant circuit to wirelessly control the actuator when the field frequency is tuned to its resonant frequency of approximately 25 MHz. Experimental characterization of the fabricated actuator showed a cumulative cantilever deflection of 160 μm for three repeated RF ON–OFF cycles at 0.6 W input power. The device was loaded with a dye solution and immersed in DI water to demonstrate wireless drug release. The qualitative result shows the successful release of the dye solution from the device reservoir. The release rate can be controlled by tuning the RF input power. We achieved a maximum average release rate of ∼0.1 μl s−1. We further conducted an in vitro study with human tumor cells (HeLa) to demonstrate the proof of concept of the developed device. The experiments show promising results towards the intended drug delivery application.
中文翻译：
具有集成的离子聚合物金属复合材料（IPMC）悬臂阀的无线激活设备，可用于有针对性的药物输送†
本文报道了一种无线供电的离子聚合物金属复合材料（IPMC）软致动器，该软致动器由外部射频（RF）磁场操作，用于靶向药物输送。一块183μm厚的IPMC悬臂阀装有嵌入式LC谐振电路，以在将现场频率调谐到其大约25 MHz的谐振频率时无线控制执行器。制成的执行器的实验特性表明，在输入功率为0.6 W的情况下，三个重复的RF ON-OFF循环的累积悬臂挠度为160μm。该设备装有染料溶液，并浸入去离子水中以演示无线药物释放。定性结果表明染料溶液已从设备容器中成功释放。释放速率可以通过调整RF输入功率来控制。-1。我们进一步用人肿瘤细胞（HeLa）进行了体外研究，以证明已开发设备的概念证明。实验表明，对于预期的药物递送应用而言，结果令人鼓舞。
更新日期：2018-09-19
中文翻译：
具有集成的离子聚合物金属复合材料（IPMC）悬臂阀的无线激活设备，可用于有针对性的药物输送†
本文报道了一种无线供电的离子聚合物金属复合材料（IPMC）软致动器，该软致动器由外部射频（RF）磁场操作，用于靶向药物输送。一块183μm厚的IPMC悬臂阀装有嵌入式LC谐振电路，以在将现场频率调谐到其大约25 MHz的谐振频率时无线控制执行器。制成的执行器的实验特性表明，在输入功率为0.6 W的情况下，三个重复的RF ON-OFF循环的累积悬臂挠度为160μm。该设备装有染料溶液，并浸入去离子水中以演示无线药物释放。定性结果表明染料溶液已从设备容器中成功释放。释放速率可以通过调整RF输入功率来控制。-1。我们进一步用人肿瘤细胞（HeLa）进行了体外研究，以证明已开发设备的概念证明。实验表明，对于预期的药物递送应用而言，结果令人鼓舞。
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