Design, synthesis, and applications of DNA–macrocyclic host conjugates,Chemical Communications

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Design, synthesis, and applications of DNA–macrocyclic host conjugates
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-19 00:00:00 , DOI: 10.1039/c8cc06716c
X Zhou ₁ , P Pathak , J Jayawickramarajah

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With this Feature Article we review, for the first time, the development of DNA–host conjugates—a nascent yet rapidly growing research focus within the ambit of DNA supramolecular chemistry. Synthetic hosts (such as cyclodextrins, cucurbiturils, and calixarenes) are well-suited to be partnered with DNA, since DNA assembly and host–guest binding both thrive in aqueous media, are largely orthogonal, and exhibit controllable and input-responsive properties. The covalent braiding of these two supramolecular synthons thus leads to advanced self-assemblies and nanostructures with exciting function that range from drug delivery agents to input-triggered switches. The latter class of DNA–host conjugates have been demonstrated to precisely control protein activity, and have also been used as modulable catalysts and versatile biosensors.

中文翻译：

DNA-大环宿主偶联物的设计、合成和应用

在这篇专题文章中，我们首次回顾了 DNA 宿主偶联物的发展——这是 DNA 超分子化学领域内新兴但迅速发展的研究重点。合成宿主（如环糊精、葫芦脲和杯芳烃）非常适合与 DNA 结合，因为 DNA 组装和主客体结合都在水介质中茁壮成长，在很大程度上是正交的，并且表现出可控和输入响应特性。因此，这两种超分子合成子的共价编织导致先进的自组装和纳米结构具有令人兴奋的功能，从药物递送剂到输入触发开关。后一类 DNA-宿主偶联物已被证明可以精确控制蛋白质活性，并且还被用作可调节的催化剂和多功能生物传感器。

更新日期：2018-09-19

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