Abstract In this study, hot extruded pure Zn and Zn-0.02Mg-0.02Cu alloy were prepared. Compared with the pure Zn, the tensile yield strength, ultimate tensile strength and hardness of the Zn-based alloy were significantly improved, reaching 216.29 ± 3.27 MPa, 262.25 ± 5.02 MPa and 74.40 ± 1.84 HV, respectively, satisfying the criteria of biodegradable stents. Electrochemical corrosion and immersion test showed that the corrosion rates of the Zn-based alloy were higher than those of pure Zn. In addition, the Zn-based alloy exhibited excellent biocompatibility for the development of zebrafish embryos and in vivo subcutaneous tissue without severe inflammatory response. These results indicate that the novel Zn-based alloy has a huge potential in cardiovascular stents.

中文翻译：

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一种用于心血管植入物的可生物降解 Zn-Mg-Cu 合金的力学性能、降解行为和生物相容性评价

摘要 本研究制备了热挤压纯Zn和Zn-0.02Mg-0.02Cu合金。与纯锌相比，锌基合金的拉伸屈服强度、极限拉伸强度和硬度显着提高，分别达到216.29±3.27 MPa、262.25±5.02 MPa和74.40±1.84 HV，满足可生物降解支架的标准. 电化学腐蚀和浸泡试验表明，锌基合金的腐蚀速率高于纯锌。此外，锌基合金对斑马鱼胚胎和体内皮下组织的发育表现出优异的生物相容性，没有严重的炎症反应。这些结果表明，新型锌基合金在心血管支架方面具有巨大的潜力。