Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) manifests as unpleasant dreams and dream-enacting behaviors during REM sleep. iRBD is currently recognized as a prodromal stage of Parkinson's disease (PD), and the majority of iRBD patients will develop PD. However, there is an approximately 10 year interval between iRBD onset and established PD, which provides neurologists a window for intervention prior to irreversible neuron damage in prodromal PD patients. In this Review, we summarize possible predictive markers of PD in iRBD on clinical assessment, heredity, neuroimaging, and electrophysiology. We hope this summary can help researchers and clinical physicians better understand the risk factors for conversion from iRBD to PD and indicate directions for neuroprotective strategies and the prediction of disease progression.

中文翻译：

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从快速的眼动睡眠行为障碍到帕金森氏病：可能的转换预测指标。

特发性快速眼动（REM）睡眠行为障碍（iRBD）在REM睡眠期间表现为不愉快的梦境和表现为梦的行为。目前，iRBD被认为是帕金森氏病（PD）的前驱阶段，大多数iRBD患者将发展为PD。但是，iRBD发作与已建立的PD之间大约有10年的间隔，这为神经病学家提供了一个窗口，可在前驱PD患者中对不可逆神经元损伤进行干预。在这篇综述中，我们总结了iRBD中PD的可能的预测标志物，包括临床评估，遗传，神经影像学和电生理学。我们希望该总结可以帮助研究人员和临床医生更好地了解从iRBD转化为PD的危险因素，并为神经保护策略和疾病进展的预测指明方向。