Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 sec. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.

近来，由于抗生素抗性细菌的增加，近红外（NIR）诱导的致病细菌的光热杀灭受到了相当大的关注。在本文中，我们报告了一种基于水溶液的简单策略，该方法可构建一种有效的光热纳米复合材料，该复合材料由聚（3,4-乙撑二氧噻吩）：聚（苯乙烯磺酸盐）（PEDOT：PSS）和琼脂糖组成，具有可热加工性，光触发性具有自我修复和出色的抗菌活性。我们的实验表明，PEDOT：PSS /琼脂糖很容易涂覆在2D玻璃基板和3D棉结构上。此外，可以将PEDOT：PSS /琼脂糖设计成各种形状的独立对象，并通过NIR光诱导损伤后的自愈作用进行修复。利用强大的NIR光吸收能力，PEDOT：PSS /琼脂糖在NIR暴露100秒钟后显示24.5°C的急剧温度升高。更重要的是，我们证明了PEDOT：PSS /琼脂糖上的温度升高通过光热转化可以在NIR辐射2分钟内快速有效地杀死近100％的致病细菌。