Lactobacillus plantarum CQPC06 (LP-CQPC06) is a newly discovered lactic acid bacterial strain. Here, the beneficial effects of this strain on C57BL/6J mice with dextran sulfate sodium-induced colitis were investigated. LP-CQPC06 was more resistant to gastric acid and bile salts than L. delbrueckii subsp. bulgaricus (LB). In the DSS-induced colitis mouse model, LP-CQPC06 treatment decreased the colon weight/length ratio and increased the colon length as compared to untreated mice with DSS-induced colitis. LP-CQPC06 also reduced the serum levels of interleukin 8 (IL-8), IL-1, tumor necrosis factor alpha, and macrophage inflammatory protein-1 alpha, as well as reducing levels of myeloperoxidase (MPO) and nitric oxide (NO) in the colon tissues of mice with DSS-induced colitis. In all cases, the effects of LP-CQPC06 were significantly stronger than those of LB. Quantitative polymerase chain reactions and western blots indicated that LP-CQPC06 increased the mRNA and protein expression levels of neuronal nitric oxide synthase, endothelial nitric oxide synthase, and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha, while decreasing the expression levels of inducible nitric oxide synthase, nuclear factor kappa-beta, C-X-C motif chemokine receptor 1 (CXCR1), and CXCR2. Thus, L. plantarum CQPC06 had a good protective effect against colitis in a mouse model via the IL-8 pathway. Therefore, L. plantarum CQPC06 might have potential uses as a probiotic for colonic protection. PRACTICAL APPLICATION In this study, a newly discovered lactic acid bacteria was investigated. This bacterial strain had a good prophylactic effect against colitis in a mouse model, and might have potential utility as a probiotic.

中文翻译：

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植物乳杆菌 CQPC06 活性通过调节 IL-8 通路预防葡聚糖硫酸钠诱导的结肠炎

植物乳杆菌CQPC06（LP-CQPC06）是一种新发现的乳酸菌株。在这里，研究了该菌株对患有葡聚糖硫酸钠诱导的结肠炎的 C57BL/6J 小鼠的有益作用。与德氏乳杆菌亚种相比，LP-CQPC06 对胃酸和胆汁盐的抵抗力更强。保加利亚（LB）。在 DSS 诱导的结肠炎小鼠模型中，与未治疗的 DSS 诱导的结肠炎小鼠相比，LP-CQPC06 治疗降低了结肠重量/长度比并增加了结肠长度。LP-CQPC06 还降低了白细胞介素 8 (IL-8)、IL-1、肿瘤坏死因子 α 和巨噬细胞炎症蛋白-1 α 的血清水平，并降低了髓过氧化物酶 (MPO) 和一氧化氮 (NO) 的水平在 DSS 诱导的结肠炎小鼠的结肠组织中。在所有情况下，LP-CQPC06的效果明显强于LB。定量聚合酶链反应和蛋白质印迹表明，LP-CQPC06 增加了 B 细胞抑制剂 α 中神经元一氧化氮合酶、内皮一氧化氮合酶和 kappa 轻多肽基因增强子核因子的 mRNA 和蛋白表达水平，同时降低了表达水平。诱导型一氧化氮合酶、核因子 kappa-beta、CXC 基序趋化因子受体 1 (CXCR1) 和 CXCR2 的水平。因此，植物乳杆菌 CQPC06 通过 IL-8 通路在小鼠模型中对结肠炎具有良好的保护作用。因此，植物乳杆菌 CQPC06 可能具有作为用于结肠保护的益生菌的潜在用途。实际应用 在这项研究中，研究了一种新发现的乳酸菌。