Plug-and-Play Nanorization of Coarse Black Phosphorus for Targeted Chemo-photoimmunotherapy of Colorectal Cancer,ACS Nano

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Plug-and-Play Nanorization of Coarse Black Phosphorus for Targeted Chemo-photoimmunotherapy of Colorectal Cancer
ACS Nano ( IF 15.8 ) Pub Date : 2018-09-17 00:00:00 , DOI: 10.1021/acsnano.8b04658
Wenquan Ou , Jeong Hoon Byeon , Raj Kumar Thapa , Sae Kwang Ku ₁ , Chul Soon Yong , Jong Oh Kim

Affiliation

Because of their extraordinary physical properties and biocompatibility, black phosphorus (BP) nanosheets (NSs) have been intensively employed in chemo-phototherapies, such as plasmonic inorganic nanoparticles or graphene NSs, over the past few years. However, most biomedical studies using BP NSs are only concerned with the optical property of BP NSs to repeatedly demonstrate chemo-phototherapeutic efficacies, although BP NSs have different properties from inorganic nanoparticles or graphene NSs, such as corrugated crystal structure, hydrophilicity, and biodegradability. Moreover, it is still a challenging issue to efficiently fabricate uniform BP NSs for clinical translation because of the top-down nature of fabrication, despite the easy preparation of coarse BP flakes. It is thus essential to explore their most suitable bioapplications as well as suggest an easy-to-access strategy to produce uniform BP NSs for realization as advanced therapeutic materials. To rationalize these issues, this report introduces a plug-and-play nanorization, ultrasonic bubble bursting, of coarse BP flakes for continuous BP NS production, and the resulting uniform NSs (∼40 nm lateral dimension, ∼0.15 polydispersity index) were used as base materials to load drug (doxorubicin), targeting agent (chitosan–polyethylene glycol), and cancer growth inhibitor (programmed death ligand 1 and small interfering RNA) for achieving efficacious chemo-photoimmunotherapy of colorectal cancer.

中文翻译：

粗黑磷的即插即用纳米化技术用于结直肠癌的靶向化学光免疫疗法

由于其非凡的物理性能和生物相容性，在过去的几年中，黑磷（BP）纳米片（NSs）已被广泛用于化学光疗，例如等离激元无机纳米粒子或石墨烯NSs。然而，尽管BP NSs具有与无机纳米颗粒或石墨烯NSs不同的特性，例如波纹状晶体结构，亲水性和生物降解性，但大多数使用BP NSs的生物医学研究仅关注BP NSs的光学性质以反复证明化学光疗功效。此外，尽管易于制备粗糙的BP薄片，但由于制造过程的自上而下的性质，有效地制备用于临床翻译的均匀BP NS仍然是一个具有挑战性的问题。因此，有必要探索它们最合适的生物应用，并提出一种易于获得的策略，以生产统一的BP NS，以实现作为先进的治疗材料。为了合理化这些问题，本报告介绍了即插即用的纳米化，超声气泡破裂，用于连续生产BP NS的粗BP薄片，并使用了均匀的NS（横向尺寸约40 nm，多分散指数约0.15）。用于装载药物（阿霉素），靶向剂（壳聚糖-聚乙二醇）和癌症生长抑制剂（编程的死亡配体1和小的干扰RNA）的基础材料，以实现有效的结直肠癌化学光免疫疗法。

更新日期：2018-09-17

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