An integrated micro-millifluidic processing system†,Lab on a Chip

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An integrated micro-millifluidic processing system†
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-09-17 00:00:00 , DOI: 10.1039/c8lc00636a
Jia Ming Zhang _{1,

2,

3,

4,

5} , Qinglei Ji _{1,

2,

3,

4,

5} , Ying Liu _{1,

2,

3,

4,

5} , Jianyong Huang _{2,

4,

5,

6,

7} , Huiling Duan _{1,

2,

3,

4,

5}

Affiliation

The development of integrated microfluidic systems/platforms concerns many fields. Current remarkable integrated systems based on stacking multi-layer polydimethylsiloxane (PDMS) require complicated fabrication and operation and still remain challenging. We propose a novel micro-millifluidic processing system (MPS) comprising three core modules: a motherboard, a control panel and microfluidic chips. Fluids are handled in sub-millichannels in a motherboard and functional operations occur in microchannels in microfluidic chips. A motherboard with versatile functional units for fluid handling was monolithically fabricated via multimaterial 3D printing, which avoids multi-layer structures, and the major disadvantage of current 3D printing, i.e. low resolution, has been overcome by integrating novel microfluidic chips based on our developed maskless lithography platform. Both numerical and experimental studies were conducted to validate our system. Potential applications such as droplet generation and distribution, microfluidic mixing and simple bacterial resistance tests have been demonstrated via our MPS.

中文翻译：

集成的微流处理系统†

集成微流体系统/平台的开发涉及许多领域。当前基于堆叠式多层聚二甲基硅氧烷（PDMS）的出色集成系统需要复杂的制造和操作，并且仍然具有挑战性。我们提出了一种新颖的微流控处理系统（MPS），该系统包括三个核心模块：主板，控制面板和微流控芯片。流体在母板的子微通道中处理，功能性操作在微流控芯片的微通道中进行。通过多材料3D打印以单片方式制造了具有用于流体处理的多功能功能单元的主板，避免了多层结构，这是当前3D打印的主要缺点，即低分辨率，已通过基于我们开发的无掩模光刻平台集成新型微流控芯片而得到解决。进行了数值和实验研究，以验证我们的系统。通过我们的MPS已经证明了潜在的应用，例如液滴的产生和分布，微流体混合以及简单的细菌抗性测试。

更新日期：2018-09-17

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