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Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1039/c8cc07047d Peng Sun 1, 2, 3, 4 , Zhen Li 4, 5, 6, 7 , Jingyun Wang 1, 2, 3, 4 , Hui Gao 4, 8, 9, 10, 11 , Xi Yang 4, 12, 13, 14, 15 , Sudong Wu 4, 16, 17, 18 , Deqiang Liu 4, 19, 20 , Qixian Chen 1, 2, 3, 4
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1039/c8cc07047d Peng Sun 1, 2, 3, 4 , Zhen Li 4, 5, 6, 7 , Jingyun Wang 1, 2, 3, 4 , Hui Gao 4, 8, 9, 10, 11 , Xi Yang 4, 12, 13, 14, 15 , Sudong Wu 4, 16, 17, 18 , Deqiang Liu 4, 19, 20 , Qixian Chen 1, 2, 3, 4
Affiliation
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A supramolecular catiomer with a metal–organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.
中文翻译：
阳离子超分子MOF平台跨信使RNA有效载荷的细胞递送†
具有金属-有机骨架（MOF）基序的超分子阳离子聚合物被开发用于制造信使RNA（mRNA）组装体。与线性Cateomer相比，树突状MOF Cateromer似乎显着提高了mRNA组件的胶体稳定性，特别是为mRNA有效负载提供了有效的保护，使其免于酶促降解，最终在靶细胞上产生了可观的mRNA转染活性。
更新日期：2018-09-14
中文翻译：
阳离子超分子MOF平台跨信使RNA有效载荷的细胞递送†
具有金属-有机骨架（MOF）基序的超分子阳离子聚合物被开发用于制造信使RNA（mRNA）组装体。与线性Cateomer相比，树突状MOF Cateromer似乎显着提高了mRNA组件的胶体稳定性，特别是为mRNA有效负载提供了有效的保护，使其免于酶促降解，最终在靶细胞上产生了可观的mRNA转染活性。
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