A Pd/C‐catalyzed domino synthesis of symmetrical and unsymmetrical ureas from aryl iodides, sodium azide, amines and CHCl₃ in water has been developed. This reaction proceeds with sequential carbonylation, Curtius rearrangement and nucleophilic addition. CHCl₃ serves as a convenient and safe alternation of CO gas in the presence of KOH. A series of urea derivatives were obtained in moderate to good yields with good functional group tolerance. Furthermore, the Pd/C catalyst could be readily recovered with slight decrease in the catalytic activity after six consecutive runs.

中文翻译：

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Pd / C催化氯仿作为水中一氧化碳源的尿素衍生物的多米诺合成

已经开发了一种Pd / C催化由水中的芳基碘化物，叠氮化钠，胺和CHCl ₃合成对称和不对称脲的多米诺骨牌。该反应以顺序的羰基化，Curtius重排和亲核加成进行。在KOH存在下，CHCl ₃可作为一种方便，安全的CO气体替代气体。以中等至良好的产率获得了具有良好的官能团耐受性的一系列脲衍生物。此外，连续六次运行后，Pd / C催化剂很容易被回收，催化活性略有下降。