Polymerization‐Induced Self‐Assembly for Artificial Biology: Opportunities and Challenges,Macromolecular Rapid Communications

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Polymerization‐Induced Self‐Assembly for Artificial Biology: Opportunities and Challenges
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2018-09-14 , DOI: 10.1002/marc.201800513
Gong Cheng ₁ , Juan Pérez-Mercader _{1,

2}

Affiliation

The study of the origin of life and current undergoing efforts to produce artificial chemical systems mimicking the behavior of natural living systems have emerged as a hot topic at the interfaces among disciplines. In these two problems, the spontaneous generation of free‐energy gradients by means of material interfaces plays a central role and, until recently, hindered progress. Polymerization‐induced self‐assembly (PISA) is a promising strategy for the formation of polymeric vesicles from a homogeneous mixture which, in the form of artificial biology, may reflect and inform the generation of vesicular structures in primitive Earth. In the past few years, PISA has been used for the construction of biomimetic vesicles or artificial protocells in artificial biology. These not only give inspiration for decoding some aspects of the origin of life in arbitrary environments but also offer potential for building innovative functional systems with a wide variety of applications. In this review, a brief summary of some of the unique possibilities offered by PISA and the development of PISA in exploration of artificial biology is provided, while some of the allied current challenges, limitations, and opportunities in this exciting field are highlighted.

中文翻译：

聚合诱导的人工生物自组装：机遇与挑战

关于生命起源的研究以及当前正在努力生产模仿自然生命系统行为的人工化学系统的研究已经成为各学科之间交界的热门话题。在这两个问题中，通过材料界面自发产生的自由能梯度起着核心作用，直到最近，它仍然阻碍了进展。聚合诱导的自组装（PISA）是一种从均质混合物中形成聚合物囊泡的有前途的策略，这种混合物以人工生物学的形式可以反映并告知原始地球中囊泡结构的产生。在过去的几年中，PISA已被用于在人造生物学中构建仿生囊泡或人造原始细胞。这些不仅为在任意环境中解码生命起源的某些方面提供了启发，而且为构建具有广泛应用的创新功能系统提供了潜力。在这篇综述中，简要概述了PISA提供的一些独特可能性以及PISA在人工生物学探索中的发展，同时重点介绍了该激动人心领域中当前的一些相关挑战，局限性和机遇。

更新日期：2018-09-14

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