This work focuses on the structure, bioactivity, corrosion, and biocompatibility characteristics of chitosan-matrix composites reinforced with various amounts of fluoride-doped diopside nanoparticles (at 20, 40, 60, and 80 wt%) deposited on stainless steel 316 L. Bioactivity studies reveal that the presence of the nanoparticles in the coatings induces apatite-forming ability to the surfaces. Based on electrochemical impedance spectroscopy and polarization experiments, the in vitro corrosion resistance of the substrate was enhanced by increasing the level of the nanoparticles in the coating. The sample containing 60% of the nanoparticles presented the highest osteoblast-like MG63 cell viability, in comparison to the other prepared and even control samples. Also, the cell attachment on the surfaces was improved with increasing the amount of the nanoparticles in the coatings. It is eventually concluded that the application of chitosan/fluoride-doped diopside nanocomposite coatings improves the bioperformance of metallic implants.

这项工作的重点是用沉积在316 L不锈钢上的各种数量的氟化物掺杂的透辉石纳米颗粒（分别为20、40、60和80 wt％）增强的壳聚糖-基质复合材料的结构，生物活性，腐蚀和生物相容性特征。研究表明，涂层中纳米颗粒的存在诱导了表面磷灰石的形成能力。基于电化学阻抗谱和极化实验，体外通过增加涂层中纳米颗粒的含量可以提高基材的耐腐蚀性。与其他制备的甚至是对照样品相比，包含60％纳米颗粒的样品呈现出最高的成骨样MG63细胞活力。而且，随着涂层中纳米颗粒的量的增加，表面上的细胞附着得以改善。最终得出结论，壳聚糖/氟化物掺杂的透辉石纳米复合材料涂层的应用改善了金属植入物的生物性能。