Introducing Students to the Medical Applications of Cross-Linked Hydrogels Using Nontoxic Materials and Experiments Suitable for Many Settings,Journal of Chemical Education

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Introducing Students to the Medical Applications of Cross-Linked Hydrogels Using Nontoxic Materials and Experiments Suitable for Many Settings
Journal of Chemical Education ( IF 2.5 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acs.jchemed.8b00067
Grigoriy Sereda ₁ , Benjamin Hawkins ₁

Affiliation

We report a series of three experiments that introduce students at different stages of their academic preparation to the medical applications of hydrogels for controlled drug delivery and wound healing. The laboratory activity bridges the fundamental concepts of chemistry (acids and bases, equilibria, solvation, and reversible esterification) with the chemistry of polymers and cross-linking, which are among the main tools of nanotechnology. The activity is customizable for students ranging from middle school to undergraduate college academic backgrounds. The two simple experiments demonstrate acid- or glucose-triggered release of a dye (model drug) from cross-linked poly(vinyl alcohol)-based gels. This mimics controlled drug delivery to more acidic cancer cells and controlled release of insulin from antidiabetic patches. The third, more technically challenging experiment demonstrates irreversible solidification of a phosphate-cross-linked chitosan gel upon heating from room temperature to body temperature. This experiment demonstrates wound healing materials that seal the wound with a nontoxic biocompatible gel. All experiments involve only nontoxic materials and can be performed under any settings.

中文翻译：

向学生介绍使用无毒材料的交联水凝胶的医学应用以及适用于多种环境的实验

我们报告了一系列三个实验，这些实验向学生介绍了他们在学术准备的不同阶段对水凝胶在药物控制和伤口愈合中的医学应用的需求。实验室活动将化学的基本概念（酸和碱，平衡，溶剂化和可逆酯化）与聚合物和交联的化学联系起来，这是纳米技术的主要工具。该活动可针对从中学到大学本科学术背景的学生进行定制。这两个简单的实验表明，酸或葡萄糖触发了染料（模型药物）从交联的聚乙烯醇基凝胶中释放出来。这模仿了药物向更多酸性癌细胞的递送，以及胰岛素从抗糖尿病药贴中的受控释放。第三，从技术上更具挑战性的实验表明，从室温加热至体温后，磷酸盐交联的壳聚糖凝胶会发生不可逆的固化。该实验表明伤口愈合材料可以用无毒的生物相容性凝胶密封伤口。所有实验仅涉及无毒材料，并且可以在任何设置下进行。

更新日期：2018-09-14

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