Ring-Opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles Using Lewis Acid,ACS Combinatorial Science

当前位置： X-MOL 学术 › ACS Comb. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ring-Opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles Using Lewis Acid
ACS Combinatorial Science Pub Date : 2018-09-10 00:00:00 , DOI: 10.1021/acscombsci.8b00071
Subhankar Panda ₁ , Nirmalya Pradhan ₁ , Debasis Manna ₁

Affiliation

An unusual transformation of indoles to pyrazoles via an aromatic ring-opening strategy has been developed. The salient feature of this strategy involves the C2–N1 bond opening and concomitant cyclization reaction of the C2═C3 bond of the indole moiety with the tosylhydrazone, which proceeds under transition-metal and ligand free conditions. This ring-opening functionalization of indoles provides a wide scope of differently substituted pyrazoles.

中文翻译：

吲哚的开环：使用路易斯酸将吲哚转化为1 H-吡唑的非常规途径

已经开发出通过芳族开环策略将吲哚不寻常地转化为吡唑。该策略的显着特征涉及C2–N1键的打开以及吲哚部分的C2═C3键与甲苯磺酰zone的环化反应，该反应在无过渡金属和无配体的条件下进行。吲哚的这种开环官能化提供了范围广泛的不同取代的吡唑。

更新日期：2018-09-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11