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Label-Free Electrochemical Immunosensor Based on Ionic Liquid Containing Dialdehyde As a Novel Linking Agent for the Antibody Immobilization
ACS Omega ( IF 3.7 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acsomega.8b01298 Youming Shen 1, 2 , Guangyu Shen 1 , Youyu Zhang 2
ACS Omega ( IF 3.7 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acsomega.8b01298 Youming Shen 1, 2 , Guangyu Shen 1 , Youyu Zhang 2
Affiliation
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Demand for label-free electrochemical immunosensor has resulted in extensive research in improving the conductivity of a sensing interface and antibody immobilization. In this paper, an electrochemical immunosensor for prostate specific antigen based on dialdehyde-functionalized ionic liquid used as a novel linking reagent to replace glutaraldehyde for the antibody immobilization is described. The novel linking reagent enhanced the conductivity of the sensing interface. Thus, the proposed immunosensor had a wider linear range of 0.05–30 ng mL–1, with a lower detection limit of 0.04 ng mL–1 compared with the immunosensor based on glutaraldehyde for the antibody immobilization.
中文翻译：
基于含二醛的离子液体作为新型抗体固定化剂的无标记电化学免疫传感器
对无标记电化学免疫传感器的需求导致了对改善传感界面的电导率和抗体固定化的广泛研究。在本文中，描述了一种基于前列腺素特异性抗原的电化学免疫传感器，该传感器基于二醛官能化的离子液体作为一种新型的连接剂，以取代戊二醛来固定抗体。新型连接试剂增强了传感界面的电导率。因此，与基于戊二醛的抗体固定化免疫传感器相比，拟议的免疫传感器线性范围更广，为0.05–30 ng mL –1，检测限较低，为0.04 ng mL –1。
更新日期：2018-09-14
中文翻译：
基于含二醛的离子液体作为新型抗体固定化剂的无标记电化学免疫传感器
对无标记电化学免疫传感器的需求导致了对改善传感界面的电导率和抗体固定化的广泛研究。在本文中，描述了一种基于前列腺素特异性抗原的电化学免疫传感器，该传感器基于二醛官能化的离子液体作为一种新型的连接剂，以取代戊二醛来固定抗体。新型连接试剂增强了传感界面的电导率。因此，与基于戊二醛的抗体固定化免疫传感器相比，拟议的免疫传感器线性范围更广，为0.05–30 ng mL –1，检测限较低，为0.04 ng mL –1。
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