Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Hybrids Based on Graphene Oxide and Porphyrin as Tools for Detection and Stabilization of DNA G-Quadruplexes
ACS Omega ( IF 3.7 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acsomega.8b01366 Ana R Monteiro 1 , Catarina I V Ramos 1 , Sara Fateixa 1 , Nuno M M Moura 1 , Maria G P M S Neves 1 , Tito Trindade 1
ACS Omega ( IF 3.7 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acsomega.8b01366 Ana R Monteiro 1 , Catarina I V Ramos 1 , Sara Fateixa 1 , Nuno M M Moura 1 , Maria G P M S Neves 1 , Tito Trindade 1
Affiliation
|
Telomerase inhibition has been an important strategy in cancer therapies, but for which effective drugs are still required. Here, noncovalent hybrid nanoplatforms containing the tetracationic 5,10,15,20-tetrakis(1-methyl-pyridinium-4-yl)porphyrin (TMPyP) and graphene oxide (GO) were prepared for promoting telomerase inhibition through the selective detection and stabilization of DNA guanine-quadruplex (G-Q) structures. Upon binding TMPyP to the GO sheets, the typical absorption bands of porphyrin have been red-shifted and the fluorescence emission was quenched. Raman mapping was used for the first time to provide new insights into the role of the electrostatic and π–π stacking interactions in the formation of such hybrids. The selective recovery of fluorescence observed during the titration of [email protected] with G-Q, resembles a selective “turn-off–on” fluorescence sensor for the detection of G-Q, paving the way for a new class of antitumor drugs.
中文翻译：
基于氧化石墨烯和卟啉的杂化物作为检测和稳定 DNA G-四链体的工具
端粒酶抑制一直是癌症治疗的重要策略，但仍需要有效的药物。在这里，制备了含有四阳离子 5,10,15,20-四（1-甲基-吡啶鎓-4-基）卟啉（TMPyP）和氧化石墨烯（GO）的非共价杂化纳米平台，用于通过选择性检测和稳定来促进端粒酶抑制DNA 鸟嘌呤四链体 (GQ) 结构。将 TMPyP 与 GO 片结合后，卟啉的典型吸收带发生红移，荧光发射被猝灭。拉曼图谱首次被用来为静电和 π-π 堆积相互作用在此类杂化物形成中的作用提供新的见解。在用 GQ 滴定 [email protected] 期间观察到的荧光选择性恢复，类似于用于检测 GQ 的选择性“关闭-开启”荧光传感器，为新型抗肿瘤药物铺平了道路。
更新日期：2018-09-14
中文翻译：
基于氧化石墨烯和卟啉的杂化物作为检测和稳定 DNA G-四链体的工具
端粒酶抑制一直是癌症治疗的重要策略，但仍需要有效的药物。在这里，制备了含有四阳离子 5,10,15,20-四（1-甲基-吡啶鎓-4-基）卟啉（TMPyP）和氧化石墨烯（GO）的非共价杂化纳米平台，用于通过选择性检测和稳定来促进端粒酶抑制DNA 鸟嘌呤四链体 (GQ) 结构。将 TMPyP 与 GO 片结合后，卟啉的典型吸收带发生红移，荧光发射被猝灭。拉曼图谱首次被用来为静电和 π-π 堆积相互作用在此类杂化物形成中的作用提供新的见解。在用 GQ 滴定 [email protected] 期间观察到的荧光选择性恢复，类似于用于检测 GQ 的选择性“关闭-开启”荧光传感器，为新型抗肿瘤药物铺平了道路。
京公网安备 11010802027423号