The importance of methyl groups in modulating biological activity, selectivity, solubility, metabolism and pharmacokinetic/pharmacodynamic properties of biologically active molecules is highlighted. The information compiled from selected beneficial cases, focuses mostly on marketed drugs and clinical candidates, and indicates that the methylation strategy has been successful in drug design.

中文翻译：

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含甲基的药物：药物设计中的甲基化

突出了甲基在调节生物活性分子的生物活性，选择性，溶解性，代谢和药代动力学/药效学性质方面的重要性。从选定的受益病例中收集的信息主要集中在市售药物和临床候选药物上，并表明甲基化策略已在药物设计中取得成功。