Self-assembly of penta-selenopeptides into amyloid fibrils†,Chemical Communications

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Self-assembly of penta-selenopeptides into amyloid fibrils†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1039/c8cc06528d
Ram P. Gokula _{1,

2,

3,

4} , Jaladhar Mahato _{1,

2,

3,

4} , Harkesh B. Singh _{1,

2,

3,

4} , Arindam Chowdhury _{1,

2,

3,

4}

Affiliation

Here, we report the synthesis of a penta-selenopeptide consisting of five benzyl protected selenocysteine residues. This selenopeptide was well characterized by both one- and two-dimensional (D) NMR spectroscopies. We find that the solution conformation is enriched with β-sheet structures, which have a propensity to self-assemble and form amyloid fibrils.

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