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Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acs.oprd.8b00153 James Gardiner 1 , Xuan Nguyen 1 , Charlotte Genet 1 , Mike D. Horne 2 , Christian H. Hornung 1 , John Tsanaktsidis 1
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1021/acs.oprd.8b00153 James Gardiner 1 , Xuan Nguyen 1 , Charlotte Genet 1 , Mike D. Horne 2 , Christian H. Hornung 1 , John Tsanaktsidis 1
Affiliation
Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.
中文翻译:
催化静态混合器,用于对利奈唑胺(Zyvox)的关键中间体进行连续流加氢
催化静态混合器(CSM)用于有效制备抗菌药物利奈唑胺(Zyvox)的关键中间体。该方法将3D打印和增材制造技术与连续流处理相结合,以产生催化加氢和快速生产目标分子的通用方法,而无需去除或回收催化剂。
更新日期:2018-09-14
中文翻译:
催化静态混合器,用于对利奈唑胺(Zyvox)的关键中间体进行连续流加氢
催化静态混合器(CSM)用于有效制备抗菌药物利奈唑胺(Zyvox)的关键中间体。该方法将3D打印和增材制造技术与连续流处理相结合,以产生催化加氢和快速生产目标分子的通用方法,而无需去除或回收催化剂。