Gamma radiation-responsive side-chain tellurium-containing polymer for cancer therapy†,Materials Chemistry Frontiers

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Gamma radiation-responsive side-chain tellurium-containing polymer for cancer therapy†
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1039/c8qm00321a
Fuqiang Fan _{1,

2,

3,

4,

5} , Shiqian Gao _{4,

5,

6,

7,

8} , Shaobo Ji _{4,

5,

6,

7,

8} , Yu Fu _{1,

2,

3,

4} , Pengpeng Zhang _{4,

9,

10,

11,

12} , Huaping Xu _{4,

5,

6,

7,

8}

Affiliation

The combination of chemotherapy and radiotherapy could not only enhance cancer treatment efficacy, but also shorten the period of the overall treatment and relieve the anxiety of the patients during the remedy. Herein, we present a novel strategy for coordinating the chemotherapy drug CDDP with a tellurium-containing polymer, which restrained the tumour cytotoxicity of these two portions. After a low dose of γ radiation, CDDP departed from the coordination complexes, and the tumour cytotoxicity of both was restored. In contrast to conventional chemotherapy, this radiation responsive system possesses specific anticancer effects and less toxicity in the non-radiation therapy. In addition, with regard to the premise of therapeutic efficiency, this system effectively lowered the radiated dosage.

中文翻译：

γ射线响应性含侧链碲的聚合物，用于癌症治疗†

化学疗法与放射疗法的结合不仅可以增强癌症的治疗效果，而且可以缩短整体治疗的时间，减轻患者在治疗过程中的焦虑感。在本文中，我们提出了一种新的策略，用于将化疗药物CDDP与含碲的聚合物配合使用，从而抑制了这两个部分的肿瘤细胞毒性。在低剂量的γ射线照射后，CDDP脱离了配位复合物，并且两者的肿瘤细胞毒性得以恢复。与常规化学疗法相比，这种放射响应系统在非放射疗法中具有特定的抗癌作用，并且毒性较小。另外，关于治疗效率的前提，该系统有效地降低了辐射剂量。

更新日期：2018-09-14

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