Purpose: Considering that oxidative stress is implicated in the pathogenesis and progression of different health conditions, we aimed to evaluate whether the redox balance of a healthy Brazilian population is associated with GPX1 polymorphisms, selenium status, lipid profile, and anthropometric and lifestyle parameters. Methods: 343 healthy adults were assessed for redox balance markers [glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity; malondialdehyde (MDA) and oxygen radical absorption capacity (ORAC)]; genotyped for the polymorphisms GPX1 Pro198Leu (rs1050450), -602A/G (rs3811699) and Arg5Pro (rs8179169); evaluated for selenium biomarkers (plasma, erythrocyte, and urine) and intake; and assessed for lipid profile. Anthropometric (BMI) and lifestyle data (physical activity, current smoking habit and alcohol consumption) were collected. Multivariable regression models were applied to investigate the possible associations. Results: Although there were no differences in GPx activity according to GPX1 Pro198Leu and -602A/G polymorphisms, this redox balance marker was positively associated with erythrocyte selenium and negatively associated with the presence of a minor allele of Pro198Leu. SOD activity was positively associated with the presence of a minor allele for these polymorphisms. ORAC showed the same pattern among Leu and G carriers and was positively associated with Leu allele presence, BMI and alcohol intake. MDA was only associated negatively with the male sex and plasma selenium. Conclusions: Our findings suggest that the redox balance of a Brazilian healthy population is associated with GPX1 polymorphisms (Pro198Leu and -602A/G), selenium status, BMI, sex, smoking habit and alcohol consumption.

中文翻译：

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健康成人巴西的氧化还原平衡与相关GPX1 Pro198Leu和-602A / G多态性，硒状态和人体测量和生活方式参数

目的：考虑到氧化应激与不同健康状况的发病机理和进展有关，我们旨在评估健康巴西人口的氧化还原平衡是否与GPX1多态性，硒状态，脂质状况以及人体测量学和生活方式参数有关。方法：对343名健康成年人的氧化还原平衡指标[谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）活性]进行了评估。丙二醛（MDA）和氧自由基吸收能力（ORAC）]；针对多态性GPX1进行基因分型Pro198Leu（rs1050450），-602A / G（rs3811699）和Arg5Pro（rs8179169）；评估硒生物标志物（血浆，红细胞和尿液）和摄入量；并评估脂质分布。收集人体测量学（BMI）和生活方式数据（体育活动，当前吸烟习惯和饮酒量）。应用多变量回归模型研究可能的关联。结果：尽管根据GPX1，GPx活性没有差异Pro198Leu和-602A / G多态性，该氧化还原平衡标记与红细胞硒呈正相关，与Pro198Leu的一个较小等位基因的存在呈负相关。SOD活性与这些多态性的次要等位基因的存在呈正相关。ORAC在Leu和G携带者中显示出相同的模式，并且与Leu等位基因的存在，BMI和酒精摄入呈正相关。MDA仅与男性和血浆硒呈负相关。结论：我们的研究结果表明，巴西的健康人群的氧化还原平衡与相关GPX1多态性（Pro198Leu和-602A / G），硒状态，BMI，性别，吸烟习惯和酒精消费。