The main objective of this review is to derive the salient features of previously developed ultrasound-assisted methods for hydroxylating graphene and Buckminsterfullerene (C₆₀). The pros and cons associated to ultrasound-assisted synthesis of hydroxy-carbon nanomaterials in designing the strategical methods for the industrial bulk production are also discussed. A guideline on the statistical methods has also been considered to further provide the scopes towards the application of the previously reported methods. Irrespective of many useful methods that have been developed in order to functionalize C₆₀ and graphene by diverse oxygenated functional groups e.g. epoxide, hydroxyl, carboxyl as well as metal/metal oxide via a combination of organic chemistry and sonochemistry, there is no report dealing exclusively on the application of ultrasonic cavitation particularly to synthesising polyhydroxylated carbon nanomaterials. On this context, this review emphasizes in investigating the critical aspects of sono-nanochemistry and the statistical approaches to optimize the variables in the sonochemical process towards a large-scale synthesis of polyhydroxylated graphene and C₆₀.

这篇综述的主要目的是推导先前开发的用于将石墨烯和巴克敏斯特富勒烯（C ₆₀）羟基化的超声辅助方法的显着特征。还讨论了超声辅助合成羟基碳纳米材料在设计工业批量生产的战略方法方面的利弊。还考虑了有关统计方法的指南，以进一步为先前报告的方法的应用提供范围。不管为使C ₆₀功能化已开发出许多有用的方法通过有机化学和声化学的结合，通过环氧化，羟基，羧基以及金属/金属氧化物等多种氧化官能团形成石墨烯，没有报道专门涉及超声空化，特别是在合成多羟基化碳纳米材料方面的应用。在此背景下，本文的重点是研究声纳化学的关键方面，以及为优化大规模合成多羟基化石墨烯和C ₆₀的声化学过程中的变量而采用的统计方法。