Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions†,Chemical Communications

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Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-14 00:00:00 , DOI: 10.1039/c8cc05905e
Shintaro Kawamura _{1,

2,

3,

4,

5} , Cassandra J. Henderson _{2,

3,

4,

5,

6} , Yuma Aoki _{1,

2,

3} , Daisuke Sekine _{2,

3,

4,

5} , Shū Kobayashi _{6,

7,

8,

9,

10} , Mikiko Sodeoka _{1,

2,

3,

4,

5}

Affiliation

We developed a practical chlorodifluoromethylation reaction mediated by diacyl peroxide generated in situ from chlorodifluoroacetic anhydride. Allylic and amino-chlorodifluoromethylations of alkenes proceeded well with the combination of this reagent, Cu(II) catalyst and a pyridine additive. Carbo- and aromatic chlorodifluoromethylations proceeded under metal-free conditions.

中文翻译：

氯二氟乙酸酐原位生成的双（氯二氟乙酰基）过氧化物对氯二氟甲基化反应的反应性和性质†

我们开发了一种实用的氯二氟甲基化反应，该反应由氯二氟乙酸酐原位生成的二酰基过氧化物介导。该试剂，Cu（II）催化剂和吡啶添加剂的组合，烯烃的烯丙基和氨基-氯二氟甲基化反应进展顺利。碳和芳香族氯二氟甲基化反应在无金属条件下进行。

更新日期：2018-09-14

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