Templated synthesis of spherical RNA nanoparticles with gene silencing activity†,Chemical Communications

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Templated synthesis of spherical RNA nanoparticles with gene silencing activity†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-13 00:00:00 , DOI: 10.1039/c8cc06994h
Michael D. Dore _{1,

2,

3} , Johans J. Fakhoury _{1,

2,

3} , Aurélie Lacroix _{1,

2,

3} , Hanadi F. Sleiman _{1,

2,

3}

Affiliation

RNA has inherent therapeutic and structural properties that make it an important component of biologically-functional nanoparticles. Using DNA-amphiphiles as synthetic templates, we report the synthesis of two classes of RNA-amphiphiles that self-assemble into spherical nanoparticles in aqueous solution and show gene silencing activity.

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