Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol†,Chemical Science

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Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol†
Chemical Science ( IF 7.6 ) Pub Date : 2018-09-13 00:00:00 , DOI: 10.1039/c8sc03339k
Shuai-Shuai Li ₁ , Xintong Lv ₁ , Didi Ren ₁ , Chang-Lun Shao ₂ , Qing Liu ₃ , Jian Xiao ₁

Affiliation

An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and o-aminobenzaldehydes via a cascade dearomatization/rearomatization/dearomatization sequence. This unique transformation addressed the drawbacks of hydride transfer-involved redox-neutral reactions.

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