Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.

肥胖相关的2型糖尿病（T2DM）的发病机理涵盖炎症和自身免疫方面的假设已得到越来越多的认识。在肥胖和T2DM状态下，观察到T辅助17（Th17）细胞和调节性T（Treg）细胞的失衡。这些改变反映了T细胞稳态的丧失，这可能导致组织和全身炎症以及T2DM的免疫力。在这篇综述中，我们将讨论有关肥胖相关的T2DM发病机制中存在Th17 / Treg介导的免疫应答这一概念的累积数据，并提供证据表明恢复Th17 / Treg失衡可能是预防和治疗糖尿病的可能途径。 T2DM及其并发症。