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Supramolecular complexes for nanomedicine
Bioorganic & Medicinal Chemistry Letters ( IF 2.7 ) Pub Date : 2018-09-13 , DOI: 10.1016/j.bmcl.2018.09.015
Chiara M.A. Gangemi , Roberta Puglisi , Andrea Pappalardo , Giuseppe Trusso Sfrazzetto

Host-guest interactions studied in supramolecular chemistry have been inspired by interactions between enzymes and substrates. Furthermore, most of the interactions involved in the cells are based on non-covalent bonds between two or more molecules. The common aspects between supramolecular chemistry and medicine have led to the development of a “new” area called “supramolecular medicine”, in which non-covalent interactions and self-assembly processes are applied within several medical fields.

The object of this Digest is to offer an account of how some macrocyclic hosts (e.g. cucurbiturils, cyclodextrins, pillararenes and calixarenes) are employed in supramolecular medicine creating new supramolecular hydrogels used as biomaterials for human tissue in regenerative medicine, and a diagnostic instrument, in-vitro and in-vivo, for the detection of diseases, as well as for the investigation of cell morphology.



中文翻译:

纳米药物的超分子复合物

在超分子化学中研究的宿主与客体之间的相互作用受到酶与底物之间相互作用的启发。此外,细胞中涉及的大多数相互作用均基于两个或多个分子之间的非共价键。超分子化学与医学之间的共同点导致了一个称为“超分子医学”的“新”领域的发展,在该领域中,非共价相互作用和自组装过程被应用于多个医学领域。

本摘要的目的是说明超分子药物中如何使用某些大环宿主(例如葫芦科植物,环糊精,柱芳烃和杯芳烃),从而在再生医学和诊断仪器使用新的超分子水凝胶作为人体组织的生物材料。体外体内,用于疾病检测以及细胞形态研究。

更新日期:2018-09-13
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