Phosphine-Catalyzed Asymmetric Organic Reactions,Chemical Reviews

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Phosphine-Catalyzed Asymmetric Organic Reactions
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-09-11 00:00:00 , DOI: 10.1021/acs.chemrev.8b00261
Huanzhen Ni ₁ , Wai-Lun Chan ₁ , Yixin Lu ₁

Affiliation

Asymmetric phosphine catalysis showcasing remarkable progress over the past two decades has emerged as a key synthetic platform for the creation of molecular frameworks encountered in medicinal chemistry and materials science. Different types of novel chiral phosphine catalysts have been developed and employed in cornucopias of organic transformations, such as annulation, addition, Morita–Baylis–Hillman, and Rauhut–Currier reactions, among others. This review summarizes all of the literature examples from late 1990s to the end of 2017, alongside their mechanistic insights whenever possible, with a very aim to trigger more intensive research in the future to render asymmetric phosphine catalysis one of the most common and reliable tools to organic chemists.

中文翻译：

膦催化的不对称有机反应

在过去的二十年中，显示出显着进步的不对称膦催化已成为创建药物化学和材料科学中遇到的分子框架的重要合成平台。已开发出各种类型的新型手性膦催化剂，并将其用于有机转化的聚宝盆中，例如环化，加成，Morita-Baylis-Hillman和Rauhut-Currier反应等。这篇综述总结了1990年代末至2017年底的所有文献实例，并在可能的情况下提供了对机械机理的深刻见解，其目的是在将来引发更深入的研究，以使不对称膦催化成为最常用和可靠的工具之一。有机化学家。

更新日期：2018-09-11

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