Molecular self-assembly offers an effective route for the rational design of chiral sensing devices. Here, cetyltrimethylammonium bromide (CTAB) was linked with the chiral calix[4]arene (CCA) via ion–dipole interactions and then an electrochemical chiral interface was constructed from the resulting self-assembled CCA-CTAB. Highly efficient recognition of tryptophan (Trp) isomers (I_l-Trp/I_d-Trp = 18.96) was achieved with the CCA-CTAB self-assembled interface. Possible mechanisms were proposed, based on density functional theory (DFT) and wettability measurements. Finally, the resulting electrochemical chiral interface was used to analyze the precise levels of l- and d-Trp in a racemic mixture of Trp isomers.

分子自组装为手性传感装置的合理设计提供了一条有效途径。在这里，十六烷基三甲基溴化铵（CTAB）通过离子-偶极相互作用与手性杯[4]芳烃（CCA）连接，然后由所得的自组装CCA-CTAB构建电化学手性界面。色氨酸（trp）异构体的高效识别（我_升-Trp /我_{ð -Trp}  = 18.96）与CCA-CTAB自组装界面来实现。根据密度泛函理论（DFT）和润湿性测量结果，提出了可能的机理。最后，将所得的电化学手性界面用于分析l-和d的精确水平-Trp是Trp异构体的外消旋混合物。