Abstract A new electrochemical sensor was developed for determination of diclofenac based on functionalized multi-walled carbon nanotubes (f-MWCNTs) and gold–platinum bimetallic nanoparticles (Au–PtNPs) modified gold electrode. The Au–PtNPs were deposited electrochemically on the surface of the f-MWCNTs modified electrode. The surface morphologies of the modified electrodes were investigated by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to evaluate the electrochemical properties of the constructed sensor. Under the optimized experimental conditions, the calibration curve was linear in the concentration range of 0.5 μM to 1000 μM of diclofenac and the detection limit was found to be 0.3 μM. The developed electrode also showed a high selectivity for diclofenac in the presence of the interfering species. The reproducibility, repeatability and stability of the electrode were satisfactory. The proposed electrochemical sensor was successfully employed for determination of diclofenac in real samples such as tablet and human urine samples.

中文翻译：

---

基于金铂双金属纳米粒子修饰的多壁碳纳米管的新型电化学传感器的制备用于测定双氯芬酸

摘要 基于功能化多壁碳纳米管 (f-MWCNTs) 和金-铂双金属纳米粒子 (Au-PtNPs) 修饰的金电极，开发了一种用于测定双氯芬酸的新型电化学传感器。Au-PtNPs 电化学沉积在 f-MWCNTs 修饰电极的表面。通过扫描电子显微镜 (SEM) 和能量色散 X 射线光谱 (EDX) 研究了修饰电极的表面形貌。循环伏安法 (CV) 和微分脉冲伏安法 (DPV) 用于评估构建的传感器的电化学性能。在优化的实验条件下，校准曲线在双氯芬酸 0.5 μM 至 1000 μM 的浓度范围内呈线性，发现检出限为 0.3 μM。在干扰物质存在的情况下，开发的电极还显示出对双氯芬酸的高选择性。电极的重现性、重复性和稳定性令人满意。所提出的电化学传感器已成功用于测定实际样品中的双氯芬酸，例如片剂和人体尿液样品。