Enzyme catalysis-induced RAFT polymerization in water for the preparation of epoxy-functionalized triblock copolymer vesicles†,Polymer Chemistry

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Enzyme catalysis-induced RAFT polymerization in water for the preparation of epoxy-functionalized triblock copolymer vesicles†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-09-12 00:00:00 , DOI: 10.1039/c8py01053f
Qin Xu _{1,

2,

3,

4,

5} , Yuxuan Zhang _{1,

2,

3,

4,

5} , Xueliang Li _{1,

2,

3,

4,

5} , Jun He _{1,

2,

3,

4,

5} , Jianbo Tan _{1,

2,

3,

4,

5} , Li Zhang _{1,

2,

3,

4,

5}

Affiliation

Enzyme catalysis is a mild and efficient technique that has been widely used in organic chemistry and polymer chemistry. In this work, enzyme catalysis-induced aqueous reversible addition–fragmentation chain transfer (RAFT) polymerization was conducted at room temperature for the preparation of a series of epoxy-functionalized triblock copolymer vesicles. Specifically, poly(glycerol monomethacrylate)-b-poly(2-hydroxypropyl methacrylate) (PGMA-PHPMA) diblock copolymer vesicles were first prepared via enzyme-initiated aqueous RAFT dispersion polymerization, and subsequently used as seeds for chain extension of glycidyl methacrylate (GlyMA) via enzyme-initiated seeded RAFT emulsion polymerization. Nanoscale phase separation was observed at higher degree of polymerization (DP) of PGlyMA. The room temperature feature of enzyme-initiated RAFT polymerization is critical to ensure the survival of epoxy groups after the polymerization. The obtained triblock copolymer vesicles were evaluated as an efficient Pickering emulsifier for hexane-in-water emulsions. In addition, the triblock copolymer vesicles were found to be tolerant to the challenge of surfactant in water. Finally, the epoxy groups in the vesicular membrane were utilized to react with ethylene diamine, allowing the preparation of cross-linked vesicles as well as silver composite vesicles.

中文翻译：

酶催化的水中RAFT聚合制备环氧官能化的三嵌段共聚物囊泡†

酶催化是一种温和而有效的技术，已广泛用于有机化学和聚合物化学中。在这项工作中，在室温下进行了酶催化诱导的水可逆加成-断裂链转移（RAFT）聚合反应，以制备一系列环氧官能化的三嵌段共聚物囊泡。具体地，首先通过酶引发的水性RAFT分散聚合制备聚（单甲基丙烯酸甘油酯）-b-聚（甲基丙烯酸2-羟丙酯）（PGMA-PHPMA）二嵌段共聚物囊泡，然后将其用作种子用于甲基丙烯酸缩水甘油酯（GlyMA）的扩链。）通过酶引发的种子RAFT乳液聚合。在较高的PGlyMA聚合度（DP）下观察到纳米级相分离。酶引发的RAFT聚合的室温特性对于确保聚合后环氧基的存活至关重要。评价得到的三嵌段共聚物囊泡作为用于水包己烷乳液的有效Pickering乳化剂。另外，发现三嵌段共聚物囊泡耐受水中表面活性剂的挑战。最后，利用囊泡膜中的环氧基与乙二胺反应，从而可以制备交联的囊泡以及银复合囊泡。

更新日期：2018-09-12

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