Enzyme-immobilized metal–organic framework nanosheets as tandem catalysts for the generation of nitric oxide†,Chemical Communications

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Enzyme-immobilized metal–organic framework nanosheets as tandem catalysts for the generation of nitric oxide†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-09-12 00:00:00 , DOI: 10.1039/c8cc05068f
Pinghua Ling _{1,

2,

3,

4,

5} , Caihua Qian _{1,

2,

3,

4,

5} , Feng Gao _{1,

2,

3,

4,

5} , Jianping Lei _{6,

7,

8,

9,

10}

Affiliation

An enzyme-immobilized metal–organic framework (MOF) nanosheet system was developed as a tandem catalyst, which converted glucose into gluconic acid and H₂O₂, and sequentially the latter could be used to catalyze the oxidation of L-arginine to generate nitric oxide in the presence of porphyrinic MOFs as artificial enzymes under physiological pH, showing great potential in cancer depleting glucose for starving-like/gas therapy.

中文翻译：

酶固定的金属-有机骨架纳米片作为串联催化剂产生一氧化氮†

开发了一种酶固定的金属-有机骨架（MOF）纳米片系统作为串联催化剂，将葡萄糖转化为葡萄糖酸和H ₂ O ₂，随后后者可用于催化L-精氨酸的氧化以生成硝酸在生理pH下以卟啉MOFs作为人工酶存在时会产生氧化氮，显示出在癌症中消耗葡萄糖的巨大潜力，可用于饥饿样/气体疗法。

更新日期：2018-09-12

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