Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis.,Chemical Communications

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Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis.
Chemical Communications ( IF 4.3 ) Pub Date : 2018-10-04 , DOI: 10.1039/c8cc04946g
Ye Tao ₁ , Scott R Gilbertson

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The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.).

中文翻译：

通过布朗斯台德酸催化非对映选择性合成1,3-二取代的异吲哚啉和sultams。

报道了双（三氟甲烷）磺酰亚胺（Tf2NH）催化末端炔烃的分子内加氢酰胺化。Et3SiH和Tf2NH的组合以高收率（最高98％）和高非对映选择性（最高99：1 dr）提供了顺式1,3-二取代的异吲哚啉和sultams。

更新日期：2018-09-11

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