Synthetic opioids (SO) are a major risk for public health across the world. These drugs can be divided into 2 categories, pharmaceutical and non-pharmaceutical fentanyls. A new generation of SO has emerged on the drug market since 2010. North America is currently facing an opioid epidemic of morbi-mortality, caused by over-prescription of opioids, illegally diverted prescribed medicines, the increasing use of heroin and the emergence of SO. Furthermore, this opioid crisis is also seen in Europe. SO are new psychoactive substances characterized by different feature such as easy availability on the Internet, low price, purity, legality, and lack of detection in laboratory tests. They have not been approved or are not recommended for human use. Opioid misuse is associated with somatic and psychiatric complications. For many substances, limited pharmacological information is available, increasing the risk of harmful adverse events. Health actors and the general population need to be clearly informed of the potential risks and consequences of the diffusion and use of SO.

中文翻译：

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新的合成阿片类药物：成瘾新格局的一部分。

合成阿片类药物（SO）是全世界公共健康的主要风险。这些药物可分为两类，药物和非药物芬太尼。自2010年以来，新一代的SO出现在毒品市场上。由于阿片类药物的过度处方，非法转移的处方药，海洛因的使用增加以及SO的出现，北美目前正面临阿片类药物致死的流行。 。此外，这种阿片类药物危机在欧洲也很常见。SO是新型精神活性物质，其特点是具有不同的功能，例如可以在Internet上轻松获得，价格低廉，纯度高，合法性强，并且在实验室测试中缺乏检测能力。它们尚未被批准或不建议用于人类。阿片类药物滥用与躯体和精神科并发症有关。对于许多物质，现有有限的药理学信息，增加了有害不良事件的风险。需要清楚地告知卫生行动者和一般人群有关SO扩散和使用的潜在风险和后果的信息。