Fluorescent nanodiamonds (FNDs) have attracted wide research interest due to their excellent optical properties and outstanding biocompatibility. Nevertheless, the complex preparation methods and high costs of FNDs still perplex their further biomedical applications. In this contribution, we developed an efficient one-step method for the preparation of water dispersible FNDs through a thiol-ene click reaction for the first time. Furthermore, a mass of carboxylic groups are introduced on the surface of FNDs, and this mass could lead to the dispersibility of FNDs in aqueous solutions. More importantly, the carboxylic groups on the surface of FNDs could further conjugate with various drug molecules and macromolecules. Therefore, the facile strategy for the preparation of FNDs with unique characteristics via the one-step thiol-ene reaction is expected to have high potential for various biomedical applications.

荧光纳米金刚石（FND）由于其出色的光学性能和出色的生物相容性而吸引了广泛的研究兴趣。然而，FNDs的复杂制备方法和高成本仍然困扰着其进一步的生物医学应用。在此贡献中，我们首次开发了一种有效的一步法，通过硫醇-烯点击反应制备水分散性FND。此外，大量的羧基被引入到FNDs的表面上，并且该质量可能导致FNDs在水溶液中的分散性。更重要的是，FNDs表面的羧基可以进一步与各种药物分子和大分子结合。所以，