Abstract Lidocaine (LC)/β-cyclodextrin (β-CD) inclusion complex was prepared. This complex was confirmed using, UV–vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA) and scanning electron microscope (SEM). This complex was used to prepare hydrogel to be used as topical pain relief. (GII) and compared with gel contains Lidocaine (GI) only. The prepared gel was evaluated by measuring the spreadability, moisture regain, viscosity, pH and drug release profile. The results received showed that the gel properties were improved by introducing the Lidocaine/β-cyclodextrin inclusion complex. The release profiles revealed that, gel with Lidocaine/β-cyclodextrin inclusion complex showed improved sustained release behaviour.

中文翻译：

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利多卡因/β-环糊精包合物作为给药系统

摘要 制备了利多卡因（LC）/β-环糊精（β-CD）包合物。使用紫外-可见光谱、傅里叶变换红外光谱 (FTIR)、热重分析 (TGA) 和扫描电子显微镜 (SEM) 证实了该复合物。该复合物用于制备用作局部止痛剂的水凝胶。(GII) 与只含有利多卡因 (GI) 的凝胶相比。通过测量铺展性、回潮率、粘度、pH 值和药物释放曲线来评估制备的凝胶。收到的结果表明，通过引入利多卡因/β-环糊精包合物改善了凝胶特性。释放曲线表明，含有利多卡因/β-环糊精包合物的凝胶显示出改善的缓释行为。