Status epilepticus (SE) is a neurological condition that frequently induces severe neuronal injury in the hippocampus, subsequent epileptogenesis and pharmacoresistant spontaneous recurrent seizures (SRS). The repeated administration of LEV (a broad-spectrum antiepileptic drug) during the post-SE period does not prevent the subsequent development of SRS. However, this treatment reduces SE-induced neurodegeneration in the hippocampus. Conversely, propylparaben (PPB) is a widely used antimicrobial that blocks voltage-dependent Na⁺ channels, induces neuroprotection and reduces epileptiform activity in vitro. The present study attempted to determine if the neuroprotective effects induced by LEV are augmented when combined with a sub-effective dose of PPB. Long-term SE-induced consequences (hyperexcitability, high glutamate release, neuronal injury and volume loss) were evaluated in the hippocampus of rats. LEV alone, as well as combined with PPB, did not prevent the occurrence of SRS. However, animals treated with LEV plus PPB showed high prevalence of low frequency oscillations (0.1–4 Hz and 8–90 bands, p < 0.001) and low prevalence of high frequency activity (90–250 bands, p < 0.001) during the interictal period. In addition, these animals presented lower extracellular levels of glutamate, decreased rate of neurodegeneration and a similar hippocampal volume compared to the control conditions. This study's results suggest that LEV associated with PPB could represent a new therapeutic strategy to reduce long-term consequences induced by SE that facilitate pharmacoresistant SRS.

癫痫持续状态（SE）是一种神经系统疾病，经常引起海马体严重的神经元损伤，随后的癫痫发生和对药物的自发性反复发作（SRS）。在SE后时期反复服用LEV（广谱抗癫痫药）不会阻止SRS的后续发展。但是，这种治疗减少了SE诱导的海马神经变性。相反，对羟基苯甲酸丙酯（PPB）是一种广泛使用的抗微生物剂，在体外能阻断电压依赖性Na ⁺通道，诱导神经保护并降低癫痫样活性。。本研究试图确定当与亚有效剂量的PPB结合时LEV诱导的神经保护作用是否增强。在大鼠海马中评估了SE引起的长期后果（过度兴奋，高谷氨酸释放，神经元损伤和体积减少）。单独使用LEV以及与PPB结合使用均不能预防SRS的发生。然而，用LEV加PPB治疗的动物在发作期表现出高频率的低频振荡（0.1–4 Hz和8–90谱带，p <0.001）和低频率的高频活动（90–250谱带，p <0.001）。时期。此外，与对照组相比，这些动物的谷氨酸盐细胞外水平较低，神经退行性变率降低，海马体积相似。这项研究'