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Drug and chemical induced photosensitivity from a clinical perspective
Photochemical & Photobiological Sciences ( IF 3.1 ) Pub Date : 2018-09-10 00:00:00 , DOI: 10.1039/c8pp00011e
Sally Ibbotson 1, 2, 3, 4, 5
Affiliation  

Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved. Some of these mechanisms will be discussed, including the most common, that of drug phototoxicity. Different types of photosensitivity are addressed with respect to clinical presentation, mechanisms and additionally the contribution to our understanding through clinically directed investigations and regulatory requirements. Repeated controlled therapeutic use of drug phototoxicity, with psoralen-UVA (PUVA) photochemotherapy and photodynamic therapy (PDT) will also be discussed. Finally, the potential for drug-induced photocarcinogenesis will also be covered.

中文翻译:

从临床角度看药物和化学诱导的光敏性

药物光敏性是一种相对普遍的现象,可能涉及多种机制。将讨论其中的一些机制,包括最常见的药物光毒性机制。针对临床表现,机制以及通过临床指导研究和法规要求对我们的理解做出的贡献,讨论了不同类型的光敏性。还讨论了通过补骨脂素-UVA(PUVA)光化学疗法和光动力疗法(PDT)重复控制药物光毒性的治疗用途。最后,还将介绍药物诱导的光致癌作用的潜力。
更新日期:2018-09-10
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