Combining In Silico Design and Biomimetic Assembly: A New Approach for Developing High-Performance Dynamic Responsive Bio-Nanomaterials.,Advanced Materials

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Combining In Silico Design and Biomimetic Assembly: A New Approach for Developing High-Performance Dynamic Responsive Bio-Nanomaterials.
Advanced Materials ( IF 27.4 ) Pub Date : 2018-09-10 , DOI: 10.1002/adma.201802306
Shengjie Ling _{1,

2,

3} , Kai Jin ₂ , Zhao Qin ₂ , Chunmei Li ₃ , Ke Zheng ₁ , Yanyan Zhao ₄ , Qi Wang ₅ , David L Kaplan ₃ , Markus J Buehler _{2,

6,

7}

Affiliation

Major challenge remains in the design and fabrication of artificial hierarchical materials that mimic the structural and functional features of these natural materials. Here, a novel biomimetic strategy to assemble hierarchical materials from biological nanobuilding blocks is demonstrated. The constituents and structures of the materials are designed by multiscale modeling and then experimentally constructed by multiscale self-assembly. The resultant materials that consist of silk nanofibrils (SNFs), hydroxyapatite (HAP), and chitin nanofibrils (CNFs) show nacre-like structures with mechanical strength and toughness better than most natural nacre and nacre-like nanocomposites. In addition, these SNF/HAP:CNF nanocomposites can be programmed into "grab-and-release" actuators due to the gradient structure of the nanocomposites as well as the high water sensitivity of each of the components, and thusshow potential applications in the design of novel third-generation biomaterials for potential clinical applications. In addition, this "in silico design and biomimetic assembly" route represents a rational, low-cost, and efficient strategy for the design and preparation of robust, hierarchical, and functional nanomaterials to meet a variety of application requirements in bio-nanotechnologies.

中文翻译：

结合硅片设计和仿生组装：开发高性能动态响应生物纳米材料的新方法。

主要挑战仍然在于模仿这些天然材料的结构和功能特征的人工分层材料的设计和制造。在这里，展示了一种从生物纳米构件组装分层材料的新颖仿生策略。通过多尺度建模设计材料的成分和结构，然后通过多尺度自组装进行实验构建。由丝纳米纤维（SNF）、羟基磷灰石（HAP）和甲壳素纳米纤维（CNF）组成的所得材料显示出类珍珠质结构，其机械强度和韧性优于大多数天然珍珠质和类珍珠质纳米复合材料。此外，由于纳米复合材料的梯度结构以及每个组件的高水敏感性，这些SNF/HAP:CNF纳米复合材料可以被编程为“抓取和释放”执行器，从而在设计中显示出潜在的应用新型第三代生物材料的潜在临床应用。此外，这种“计算机设计和仿生组装”路线代表了一种合理、低成本和高效的策略，用于设计和制备坚固的、分层的和功能性的纳米材料，以满足生物纳米技术的各种应用需求。

更新日期：2018-09-10

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