Porcine head is often used as a human surrogate in traumatic head injury research. Extensive research on mechanical properties of adult human/porcine brain tissues has been performed previously; however, very limited data is available for children, which is particular important for modeling the pediatric traumatic brain injury (TBI). In this study, uniaxial compression tests at strain rates of 0.01/s, 1/s and 50/s up to 50% strain were performed for the corona radiata, corpus callosum, thalamus, cortex, cerebellum and brainstem of 8-week-old piglets. No significant difference in tissue strength was found among the cerebrum regions of cortex, thalamus, corona radiata and corpus callosum. The average stress of cerebellum was approximate 21% and 15% higher than that of cerebrum at a strain of 0.25 and 0.5, respectively, but it did not reach statistical significant level than most of the cerebrum regions. Brainstem was the stiffest among these 6 regions, and it was significant stiffer than most regions of cerebrum, with average stress of about 28% and 40% higher at a strain of 0.25 and 0.5, respectively. The strengths of all these three regions showed significant strain-rate dependent characteristics, with the strain rate increasing from 0.01/s to 50/s, the average stress of cerebrum, cerebellum and brainstem increased to approximate 4.6, 6.3 and 6.3 times, respectively at a strain of 0.25; and increased to approximate 1.9, 2.6, and 2.5 times, respectively at a strain of 0.5. One-term Ogden model was used to fit the experimental data to obtain the material parameters and numerical simulation was performed on the compression of cerebrum specimen. Results show that the constitutive model and the calibrated parameters can well represent the compressive behavior of the brain tissue at different strain rates. The results of this study are useful for developing biofidelic pediatric brain FE models and further predict the brain injuries under impact conditions.

猪头在创伤性颅脑损伤研究中经常被用作人类的替代物。先前已经对成人/猪脑组织的机械性能进行了广泛的研究；但是，对于儿童而言，数据非常有限，这对于建模小儿创伤性脑损伤（TBI）尤为重要。在这项研究中，对8周龄的电晕放射线，体，丘脑，皮层，小脑和脑干进行了单轴压缩试验，分别以0.01 / s，1 / s和50 / s的应变率进行了高达50％的应变。仔猪。在皮质，丘脑，电晕和and体的大脑区域之间，组织强度没有显着差异。在0.25和0.5的应变下，小脑的平均压力分别比大脑高21％和15％，但它没有达到大多数大脑区域的统计显着水平。脑干是这六个区域中最硬的，并且比大多数大脑区域要硬得多，在0.25和0.5的应变下，平均应力分别高出约28％和40％。这三个区域的强度均显示出显着的应变率相关特性，应变率从0.01 / s增加至50 / s，大脑，小脑和脑干的平均应力分别在30℃时增加到大约4.6倍，6.3倍和6.3倍。 0.25的应变；并且在0.5的应变下分别增加到大约1.9、2.6和2.5倍。用一期Ogden模型拟合实验数据获得材料参数，并对大脑标本的压缩进行数值模拟。结果表明，本构模型和校正后的参数可以很好地代表不同应变率下脑组织的压缩行为。这项研究的结果可用于开发生物理想的儿科大脑有限元模型，并进一步预测撞击条件下的脑损伤。