Recent Progress in Solid‐State Nanopores,Advanced Materials

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Recent Progress in Solid‐State Nanopores
Advanced Materials ( IF 27.4 ) Pub Date : 2018-09-10 , DOI: 10.1002/adma.201704680
Kidan Lee ₁ , Kyeong-Beom Park ₁ , Hyung-Jun Kim ₁ , Jae-Seok Yu ₁ , Hongsik Chae ₁ , Hyun-Mi Kim ₂ , Ki-Bum Kim _{1,

2}

Affiliation

The solid‐state nanopore has attracted much attention as a next‐generation DNA sequencing tool or a single‐molecule biosensor platform with its high sensitivity of biomolecule detection. The platform has advantages of processability, robustness of the device, and flexibility in the nanopore dimensions as compared with the protein nanopore, but with the limitation of insufficient spatial and temporal resolution to be utilized in DNA sequencing. Here, the fundamental principles of the solid‐state nanopore are summarized to illustrate the novelty of the device, and improvements in the performance of the platform in terms of device fabrication are explained. The efforts to reduce the electrical noise of solid‐state nanopore devices, and thus to enhance the sensitivity of detection, are presented along with detailed descriptions of the noise properties of the solid‐state nanopore. Applications of 2D materials including graphene, h‐BN, and MoS₂ as a nanopore membrane to enhance the spatial resolution of nanopore detection, and organic coatings on the nanopore membranes for the addition of chemical functionality to the nanopore are summarized. Finally, the recently reported applications of the solid‐state nanopore are categorized and described according to the target biomolecules: DNA‐bound proteins, modified DNA structures, proteins, and protein oligomers.

中文翻译：

固态纳米孔的最新进展

固态纳米孔以其对生物分子的高灵敏度检测而作为下一代DNA测序工具或单分子生物传感器平台备受关注。与蛋白质纳米孔相比，该平台具有可加工性，装置的坚固性和纳米孔尺寸的灵活性的优点，但是具有不足的空间和时间分辨率以用于DNA测序。在此，总结了固态纳米孔的基本原理以说明该设备的新颖性，并就该平台在设备制造方面的性能进行了说明。努力减少固态纳米孔装置的电噪声，从而提高检测灵敏度，介绍了有关固态纳米孔的噪声特性的详细说明。二维材料的应用，包括石墨烯，h-BN和MoS₂作为一个纳米孔膜，以增强纳米孔检测的空间分辨率，并且在纳米孔膜用于添加的化学官能纳米孔有机涂层进行了总结。最后，根据目标生物分子对最近报道的固态纳米孔的应用进行分类和描述：DNA结合蛋白，修饰的DNA结构，蛋白和蛋白寡聚体。

更新日期：2018-09-10

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